Not all cancers need to be aggressively treated. Because there are significant side effects and risks of cancer therapy. Cancer overtreatment is a common problem in prostate cancer. Dr. Mark Emberton, MD. But it's a difficult concept, cancer overdiagnosis. Dr. Anton Titov, MD. But it's very important concept. Yes. It's important to bring to people's attention that not all cancers need to be aggressively treated. Because there are significant side effects and risks of cancer therapy. Correct! The question in prostate is not to find cancer, it's to find *clinically significant* cancer. And cancer overdiagnosis is even more complicated than that. A clinically significant cancer in a 55 year-old man is going to look very different to a clinically significant cancer in an 80-year old man. MRI allows us to make those judgments on prostate cancer. So if I see a slightly abnormal MRI in a 55-year-old man, I have quite a low threshold for prostate biopsy. If I see a slightly abnormal MRI in an 80-year-old man, I'm happy. As long as I can't see a reasonably large cancer in an 80-year-old, I'm content not to do prostate biopsy in that person. Because 80-year-old man has much less life expectancy than a 55 year-old man. Dr. Anton Titov, MD. MRI technology is standardized. So it's possible to do MRI in one location of the world but have it read by very sophisticated specialists in another part of the world. Dr. Mark Emberton, MD. Correct, correct! And of course, these days we will use the cloud servers to review MRI. The MRI can be held in the cloud server and it can be accessed in cloud-based DICOM server. Absolutely!